Document Type

Journal Article

Department/Unit

Department of Chemistry

Abstract

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ1–40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ1–40 peptide on the basis of their emission response.

Publication Year

2015

Journal Title

Scientific Reports

Volume number

5

Publisher

Nature Publishing Group

First Page (page number)

14619

Referreed

1

DOI

10.1038/srep14619

ISSN (print)

20452322

Link to Publisher’s Edition

http://dx.doi.org/10.1038/srep14619

Additional Files

JA-5034-28939_publisher_suppl.pdf (865 kB)

Included in

Chemistry Commons

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