Department of Chemistry
We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ1–40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ1–40 peptide on the basis of their emission response.
Nature Publishing Group
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Lu, Lihua, Hai-Jing Zhong, Modi Wang, See-Lok Ho, Hung Wing Li, Chung-Hang Leung, and Dik Lung Ma. "Inhibition of beta-amyloid fibrillation by luminescent iridium(III) complex probes." Scientific Reports 5 (2015): 14619.