Document Type

Journal Article

Department/Unit

Department of Chemistry

Abstract

Group 9 transition metal complexes have been widely explored as therapeutic agents due to their unique geometry, their propensity to undergo ligand exchanges with biomolecules and their diverse steric and electronic properties. These metal complexes can offer distinct modes of action in living organisms compared to carbon-based molecules. In this study, we investigated the antimicrobial and anti-proliferative abilities of a series of cyclometallated iridium(III) complexes. The iridium(III) complex 1 inhibited the growth of S. aureus with MIC and MBC values of 3.60 and 7.19 μM, respectively, indicating its potent bactericidal activity. Moreover, complex 1 also exhibited cytotoxicity against a number of cancer cell lines, with particular potency against ovarian, cervical and melanoma cells. This cyclometallated iridium(III) complex is the first example of a substitutionally-inert, Group 9 organometallic compound utilized as a direct and selective inhibitor of S. aureus.

Publication Year

2015

Journal Title

Scientific Reports

Volume number

5

Publisher

Nature Publishing Group

First Page (page number)

14544

Referreed

1

DOI

10.1038/srep14544

ISSN (print)

20452322

Link to Publisher’s Edition

http://dx.doi.org/10.1038/srep14544

Additional Files

JA-5034-28941_publisher_suppl.pdf (263 kB)

Included in

Chemistry Commons

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