Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

A G-pentaplex-based assay for Cs+ ions in aqueous solution using a luminescent Ir(III) complex

Abstract

A series of 5 randomly designed in-house cyclometalated Ir(III) complexes were examined for their application in G-pentaplex probes and the “proof-of-principle” concept in G-pentaplex-based Cs+ ions detection. The G-pentaplex-forming sequence (DNA1, 5′-T(iG)4T-3′, where iG=isoguanine) is present in single strand DNA form ab initio, however, the addition of Cs+ ions lead to formation of the intermolecular G-pentaplex structure which is identified by the novel Ir(III) complex 1 afterward and produce an enhanced luminescence signal for Cs+ ions monitoring. To the best of our knowledge, this is the first G-pentaplex probe and also the first G-pentaplex-based label-free detection platform for Cs+ ions reported in the literature. The monitoring of spiked Cs+ ions in natural water samples demonstrates the potential application and technical sound of this “proof-of-principle” concept sensing platform.

Publication Year

2016

Journal Title

Biosensors and Bioelectronics

Volume number

77

Publisher

Elsevier

First Page (page number)

609

Last Page (page number)

612

Referreed

1

DOI

10.1016/j.bios.2015.10.026

ISSN (print)

09565663

Link to Publisher’s Edition

http://dx.doi.org/10.1016/j.bios.2015.10.026

Keywords

Label-free detection, Iridium(III) complex, G-pentaplex, Cs+

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