Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Utilization of G-quadruplex-forming aptamers for the construction of luminescence sensing platforms

Abstract

Aptamers are nucleic acid sequences that can recognize and bind to analytes with high affinity and selectivity. Intriguingly, a number of aptamers undergo a conformational change within the G-quadruplex motif upon ligand binding. This Minireview aims to highlight interesting examples of luminescent G-quadruplex aptamer-based probes that have been developed in recent years. Various mechanisms and sensing modes are described, and the outlook and future directions of this field are also discussed.

Publication Year

2017

Journal Title

ChemPlusChem

Volume number

81

Issue number

1

Publisher

Wiley-VCH Verlag

First Page (page number)

8

Last Page (page number)

17

Referreed

1

DOI

10.1002/cplu.201600036

ISSN (electronic)

21926506

Link to Publisher’s Edition

http://dx.doi.org/10.1002/cplu.201600036

Keywords

aptamers, G-quadruplexes, luminescence, oligonucleotides, sensors

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