Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction

Abstract

The natural product-like compound 1 was identified as a direct inhibitor of the menin–MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.

Publication Year

2016

Journal Title

Chemical Communications

Volume number

52

Issue number

34

Publisher

Royal Society of Chemistry

First Page (page number)

5788

Last Page (page number)

5791

Referreed

1

DOI

10.1039/C6CC01079B

ISSN (print)

13597345

Link to Publisher’s Edition

http://dx.doi.org/10.1039/C6CC01079B

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