Department of Chemistry
Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular “epidrugs” have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.
Coordination Chemistry Reviews
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Transition metal complexes, Epigenetic, Epidrugs, Histone, Chromatin-modifying enzymes
Leung, Chung-Hang, Li-Juan Liu, Ka-Ho Leung, and Dik Lung Ma. "Epigenetic modulation by inorganic metal complexes." Coordination Chemistry Reviews 319 (2016): 25-34.