Document Type

Journal Article

Department/Unit

Department of Chemistry

Abstract

Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular “epidrugs” have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.

Publication Year

2016

Journal Title

Coordination Chemistry Reviews

Volume number

319

Publisher

Elsevier

First Page (page number)

25

Last Page (page number)

34

Referreed

1

DOI

10.1016/j.ccr.2016.03.014

ISSN (print)

00108545

Link to Publisher’s Edition

http://dx.doi.org/10.1016/j.ccr.2016.03.014

Keywords

Transition metal complexes, Epigenetic, Epidrugs, Histone, Chromatin-modifying enzymes

Available for download on Wednesday, August 01, 2018

Included in

Chemistry Commons

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