Department of Chemistry
Identification of an iridium(III)-based inhibitor of tumor necrosis factor-α
The novel iridium(III) complex 1 was verified as a potent inhibitor of the TNF-α–TNFR protein–protein interaction in vitro and in cellulo. The iridium(III) center plays a critical role in organizing the structure of the bioactive metal complex, as the isolated ligands were found to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity and TNF-α–TNFR binding. 1 represents a promising scaffold for the further development of more potent organometallic TNF-α inhibitors.
Journal of Medicinal Chemistry
American Chemical Society
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Kang, Tian-Shu, Zhifeng Mao, Chan-Tat Ng, Modi Wang, Wanhe Wang, Chunming Wang, Simon Ming-Yuen Lee, Yitao Wang, Chung-Hang Leung, and Dik Lung Ma. "Identification of an iridium(III)-based inhibitor of tumor necrosis factor-α." Journal of Medicinal Chemistry 59.8 (2016): 4026-4031.