Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

An individual nanocube-based plasmonic biosensor for real-time monitoring the structural switch of the telomeric G-quadruplex

Abstract

Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

Publication Year

2016

Journal Title

Small

Volume number

12

Issue number

21

Publisher

Wiley

First Page (page number)

2913

Last Page (page number)

2920

Referreed

1

DOI

10.1002/smll.201600041

ISSN (print)

16136810

Link to Publisher’s Edition

http://dx.doi.org/10.1002/smll.201600041

Keywords

core-shell nanocubes, G-quadruplex, localized surface plasmon resonance, nanoaptasensors, biosensors

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