Department of Chemistry
An individual nanocube-based plasmonic biosensor for real-time monitoring the structural switch of the telomeric G-quadruplex
Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.
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core-shell nanocubes, G-quadruplex, localized surface plasmon resonance, nanoaptasensors, biosensors
Tian, Yuanyuan, Lei Zhang, Jingjing Shen, Lingzhi Wu, Hongzhang He, Dik Lung Ma, Chung-Hang Leung, Weibing Wu, Quli Fan, Wei Huang, and Lianhui Wang. "An individual nanocube-based plasmonic biosensor for real-time monitoring the structural switch of the telomeric G-quadruplex." Small 12.21 (2016): 2913-2920.