Title

A systematic review of Si-Miao-Yong-An decoction for the treatment of diabetic foot

Year of Award

2015

Degree Type

Dissertation

Degree Name

Master of Chinese Medicine (MCM)

Department

School of Chinese Medicine.

Principal Supervisor

Xu, Min

Keywords

Diabetes, Diabetic foot, Medicine, Chinese, Treatment

Language

English

Abstract

Introduction: Diabetic foot (DF) is a common complication in patients with diabetes mellitus. Due to arterial abnormalities and diabetic neuropathy, as well as a tendency to delayed wound healing, infection or gangrene of the foot is relatively common. Early study indicated Si-Miao-Yong-An (SMYA) decoction is the most chosen Chinese herbal formulae in the treatment of DF. The aim of this study is to assess the quality of current evidence, and systematic review the effectiveness and safety of SMYA decoction for the treatment of DF. Method: (1) Search strategy: a special protocol was designed, and electronic databases and hand-search materials were used for screening eligible trials. (2) Inclusive criteria: randomized controlled trials (RCTs) to examine the efficacy and/or safety of SMYA decoction in DF treatments were valid. (3)Data analysis: the Jadad’s scale was used to assess the quality of eligible trials. Result: Total 23 RCTs met the inclusion criteria. Among those, 1341 patients are involved, 702 patients were treated by SYMA decoction. 22 trails using SMYA decoction combined WM claimed that they showed a statistically significant advantages over the treatments using WM alone in reducing DF symptoms. Only 1 RCT reported adverse events related to SMYA decoction, but less than WM treatment. Conclusion: All available evidence points to the fact that SMYA decoction may benefit to those diabetes patients with foot problem. However, due to the poor quality of included trials, more high-quality trials are required to substantiate or refute these early findings.

Comments

Abstract also in Chinese ; "Thesis submitted to the School of Chinese Medicine" ; "Principal supervisor: Doctor Xu Min" ; "Thesis (MCM)--Hong Kong Baptist University, 2015" ; "Includes bibliographical references (leaves 37-40)"

Copyright

The author retains all rights to this work. The author has signed an agreement granting HKBU a non-exclusive license to archive and distribute their thesis.

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