http://dx.doi.org/10.1002/ptr.3269">
 

Document Type

Journal Article

Department/Unit

Department of Biology

Title

Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells

Language

English

Abstract

Aggregated beta-amyloid (Aβ) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and schisandrin C) isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) againstAβ 25-35 and homocysteine toxicity in PC12 cells was studied. Exposure of PC12 cells to 0.5 μM Aβ25-35 caused significant cell death, increased the number of apoptotic cells, elevated reactive oxygen species, increased the levels of the pro-apoptotic protein Bax and caspase-3 activation. All these effects induced byAβ25-35 were markedly reversed by schisandrin B and schisandrin C pretreatment, while schisandrin and schisantherin A had no obvious effects. Meanwhile, schisandrin B and schisandrin C reversed homocysteine-induced cytotoxicity. The results indicated that schisandrin B and schisandrin C protected PC12 cells against Aβ toxicity by attenuating ROS production and modulating the apoptotic signal pathway through Bax and caspase-3. Further structure-activity analysis of Schisandra lignans and evaluations of their neuroprotective effects using AD animal models are warranted. Copyright © 2010 John Wiley & Sons, Ltd.

Keywords

Beta-amyloid, Dibenzocyclooctadiene lignans, Homocysteine, Schisandra chinensis (Turcz.) Baill., Schisandrin B, Schisandrin C

Publication Date

2011

Source Publication Title

Phytotherapy Research

Volume

25

Issue

3

Start Page

435

End Page

443

Publisher

Wiley

ISSN (print)

0951418X

ISSN (electronic)

10991573

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