Document Type

Journal Article

Department/Unit

Department of Biology

Title

Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats

Language

English

Abstract

Parkinson's disease is caused by the degeneration of dopaminergic neurons in substantia nigra. There is no current promising treatment for neuroprotection of dopaminergic neurons. Ceftriaxone is a beta-lactam antibiotic and has been reported to offer neuroprotective effects (Rothstein, J.-D., Patel, S., Regan, M.-R., Haenggeli, C., Huang, Y.-H., Bergles, D.-E., Jin, L., Dykes, H.-M., Vidensky, S., Chung, D.-S., Toan, S.-V., Bruijn, L.-I., Su, Z.-Z., Gupta, P., and Fisher, P.-B. (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature433, 73-77). In the present study, efficacy of ceftriaxone in neuroprotection of dopaminergic neurons and amelioration of motor deficits in a rat model of Parkinson's disease were investigated. Ceftriaxone was administrated in 6-hydroxydopamine-lesioned rats. Using behavioral tests, grip strength and numbers of apomorphine-induced contralateral rotation were declined in the ceftriaxone-treated group. More importantly, cell death of dopaminergic neurons was found to decrease. In addition, both the protein expression and immunoreactivity for GLT-1 were up-regulated. The present results strongly indicate that ceftriaxone is a potential agent in the treatment of Parkinson's disease. © 2011 American Chemical Society.

Keywords

Animal model of Parkinson's disease, antibiotic, basal ganglia, ceftriaxone, degeneration of dopaminergic neurons, glutamate transporter, glutamate transporter subtype 1

Publication Date

2012

Source Publication Title

ACS Chemical Neuroscience

Volume

3

Issue

1

Start Page

22

End Page

30

Publisher

American Chemical Society

DOI

10.1021/cn200072h

Link to Publisher's Edition

http://dx.doi.org/10.1021/cn200072h

ISSN (print)

19487193

ISSN (electronic)

19487193

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