Document Type

Journal Article

Department/Unit

Department of Biology

Title

Hydroxylated and methoxylated polybrominated diphenyl ethers in blood plasma of humans in Hong Kong

Language

English

Abstract

Hydroxylated (OH-) and methoxylated (MeO-) polybrominated diphenyl ethers (PBDE) are suspected endocrine disruptors. Little is known about the accumulation or sources of these chemicals in tissues of humans, particularly those residing in Hong Kong, which is one of the most densely populated cities in the world. Seven MeO-BDEs, fifteen OH-BDEs and three bromophenols (BRPs) were analyzed in blood plasma of 116 humans that had been collected by the Hong Kong Red Cross. Total concentrations of MeO-BDEs, OH-BDEs and BRPs ranged from 3.8×102 to 52×103pgg-1 lipid (median 4.5×103pgg-1), 5.3 to 4.9×102pgg-1 lipid (81pgg-1) and ND to 1.1×102pgg-1 lipid (3.7pgg-1), respectively. 3-MeO-BDE-47, 6-OH-BDE-47 and 2, 4, 5-TBP were the predominant MeO-BDEs, OH-BDEs and BRPs, respectively. These results are consistent with accumulation of MeO-BDEs, OH-BDEs and BRPs in human plasma being primarily from natural products and inter-conversion of natural products. Coefficients of determination for some pairs of congeners such as 3-OH-BDE-100 and 6-OH-BDE-47, 6-OH-BDE-85 and 5'-OH-BDE-99, and 2, 4-DBP and 6-OH-BDE-85, were near 1.0, which is consistent with them having common sources. Patterns of relative concentrations of the target analytes were similar in the diet, particularly fish, as in blood plasma of humans, which suggests that the diet and particularly seafood might be a source of these compounds and PBDEs. Furthermore, biotransformation of natural chemicals such as OH-BDEs to BRPs might be the primary route of their elimination from humans. © 2012 Elsevier Ltd.

Keywords

Asia, Bromophenols, Diet, Natural products, PBDE, Sources

Publication Date

2012

Source Publication Title

Environment International

Volume

47

Start Page

66

End Page

72

Publisher

Elsevier

DOI

10.1016/j.envint.2012.06.004

ISSN (print)

01604120

ISSN (electronic)

18736750

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