Document Type

Journal Article

Department/Unit

Department of Biology

Title

Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Language

English

Abstract

In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

Keywords

Extracellular signal-regulated kinase signaling pathway, Motor symptom, N-methyl-D-aspartate receptor 2B, Parkinson's disease, Small interference RNA

Publication Date

2013

Source Publication Title

Neurosignals

Volume

21

Issue

2-1

Start Page

42

End Page

54

Publisher

Karger

DOI

10.1159/000334720

Link to Publisher's Edition

http://dx.doi.org/10.1159/000334720

ISSN (print)

1424862X

ISSN (electronic)

14248638

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