http://dx.doi.org/10.1016/j.jhazmat.2013.01.034">
 

Document Type

Journal Article

Department/Unit

Department of Biology

Title

Blood plasma concentrations of endocrine disrupting chemicals in Hong Kong populations

Language

English

Abstract

In this study we report the human plasma concentrations of some common endocrine disrupting chemicals (EDCs) in the Hong Kong population. We have analyzed 153 plasma samples for the contaminants by methods involving labeled standards spiked into the samples. Quantification was performed using high performance liquid chromatography tandem mass spectrometry for bisphenol-A (BPA) and perfluorinated compounds (PFCs), and gas chromatography mass spectrometry methods for phthalates. We found BPA, several types of PFCs and phthalates in over 90% of the plasma samples. Perfluorooctane sulfonate (PFOS) was the dominant PFC, followed by perfluroroctanoic acid (PFOA) and perfluorohexane sulfonate (PFHxS). Eight out of ten phthalates were detected, with bis(2-ethylhexyl) phthalate (DEHP) as the most abundant, followed by bis(2-methoxyethyl) phthalate (DMEP) and dioctyl phthalate (DnOP). The levels of PFOS, PFOA, PFHxS and perfluorohexanoic acid (PFHxA) were significantly higher in the male plasma samples (p< 0.05), while the mean plasma levels of DEHP and n-butyl benzyl phthalate (BBP) were significantly higher in the young age group (p< 0.02). The presence of the selected EDCs in human blood plasma indicates common exposure routes among different population cohorts. Although the plasma levels of the EDCs were comparable to other countries, regular monitoring of human blood EDC contamination levels is necessary to provide a time-trend database for the estimation of exposure risk and to formulate appropriate public health policy. © 2013 Elsevier B.V.

Keywords

Bisphenol A, Human plasma, Internal exposure, Perfluorinated compounds, Phthalates, Plasticizers

Publication Date

2013

Source Publication Title

Journal of Hazardous Materials

Volume

261

Start Page

763

End Page

769

Publisher

Elsevier

ISSN (print)

03043894

ISSN (electronic)

18733336

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