http://dx.doi.org/10.1016/j.semcdb.2014.04.013">
 

Document Type

Journal Article

Department/Unit

Department of Biology

Title

Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis

Language

English

Abstract

Non-receptor protein tyrosine kinases are cytoplasmic kinases that activate proteins by phosphorylating tyrosine residues, which in turn affect multiple functions in eukaryotic cells. Herein, we focus on the role of non-receptor protein tyrosine kinases, most notably, FAK, c-Yes and c-Src, in the transport of spermatids across the seminiferous epithelium during spermatogenesis. Since spermatids, which are formed from spermatocytes via meiosis, are immotile haploid cells, they must be transported by Sertoli cells across the seminiferous epithelium during the epithelial cycle of spermatogenesis. Without the timely transport of spermatids across the epithelium, the release of sperms at spermiation fails to occur, leading to infertility. Thus, the molecular event pertinent to spermatid transport is crucial to spermatogenesis. We provide a critical discussion based on recent findings in this review. We also provide a hypothetical model on spermatid transport, and the role of non-receptor protein tyrosine kinases in this event. We also highlight areas of research that deserve attention by investigators in the field. © 2014 Elsevier Ltd.

Keywords

Blood-testis barrier, C-Src, C-Yes, Cell adhesion, FAK, Seminiferous epithelial cycle, Spermatogenesis, Spermiation, Spermiogenesis, Testis

Publication Date

2014

Source Publication Title

Seminars in Cell and Developmental Biology

Volume

30

Start Page

65

End Page

74

Publisher

Elsevier

ISSN (print)

10849521

ISSN (electronic)

10963634

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