Document Type

Journal Article

Department/Unit

Department of Biology

Title

Targeting testis-specific proteins to inhibit spermatogenesis: Lesson from endocrine disrupting chemicals

Language

English

Abstract

Introduction: Exposure to endocrine disrupting chemicals (EDCs) has recently been linked to declining fertility in men in both developed and developing countries. Since many EDCs possess intrinsic estrogenic or androgenic activities, thus, the gonad is one of the major targets of EDCs. Areas covered: For the past 2 decades, studies found in the literature regarding the disruptive effects of these EDCs on reproductive function in human males and also rodents were mostly focused on oxidative stress-induced germ cell apoptosis, disruption of steroidogenesis, abnormal sperm production and disruption of spermatogenesis in particular cell adhesion function and the blood-testis-barrier (BTB) function. Herein, we highlight recent findings in the field illustrating testis-specific proteins are also targets of EDCs. Expert opinion: This information should be helpful in developing better therapeutic approach to manage ECD-induced reproductive toxicity. This information is also helpful to identify potential targets for male contraceptive development. © Informa UK, Ltd.

Keywords

Blood-testis-barrier, Endocrine disrupting chemicals, Spermatogenesis, Steroidogenesis, Testis, Testis-specific proteins

Publication Date

2013

Source Publication Title

Expert Opinion on Therapeutic Targets

Volume

17

Issue

7

Start Page

839

End Page

855

Publisher

Informa Healthcare

DOI

10.1517/14728222.2013.791679

ISSN (print)

14728222

ISSN (electronic)

17447631

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