Department of Biology
Germ cell transport across the seminiferous epithelium during spermatogenesis
Transport of germ cells across the seminiferous epithelium is crucial to spermatogenesis. Its disruption causes infertility. Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes. We critically evaluate these findings and provide a hypothetical framework that regulates these events. © 2014 Int. Union Physiol. Sci./Am. Physiol. Soc.
Source Publication Title
American Physiological Society
Link to Publisher's Edition
Xiao, Xiang, Dolores D. Mruk, Chris K. C. Wong, and C. Yan Cheng. "Germ cell transport across the seminiferous epithelium during spermatogenesis." Physiology 29.4 (2014): 286-298.