http://dx.doi.org/10.1016/j.phymed.2014.02.005">
 

Document Type

Journal Article

Authors

Kim-Hung Lam, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Kenneth Ka-Ho Lee, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Roberto Gambari, Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara
Stanton Hon-Lung Kok, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Tsz-Wai Kok, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Albert Sun-Chi Chan, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist University
Zhao-Xiang Bian, Clinical Division, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Wai-Yeung Wong, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist UniversityFollow
Raymond Siu-Ming Wong, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Fung-Yi Lau, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
See-Wai Tong, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Kit-Wah Chan, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital
Chor-Hing Cheng, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Chung-Hin Chui, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic UniversityFollow
Johnny Cheuk-On Tang, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University

Department/Unit

Department of Chemistry

Title

Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue

Language

English

Abstract

The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect. © 2014 Elsevier GmbH.

Keywords

Alkaloid analogues, Anti-tumour, Galipea longiflora

Publication Date

2014

Source Publication Title

Phytomedicine

Volume

21

Issue

6

Start Page

877

End Page

882

Publisher

Elsevier

ISSN (print)

09447113

ISSN (electronic)

1618095X

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