Department of Chemistry
Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue
The quinolinium chloride salt of 8-hydroxyqinolinecarbaldehyde (2-Formyl-8-hydroxy-quinolinium chloride) was prepared as Galipea longiflora alkaloid analogue and its anticancer activity was evaluated both in vitro and in vivo. This chloride salt was found to show certain degree of selectivity between hepatoma cells and normal hepatocytes in vitro. Athymic nude mice Hep3B xenograft model further demonstrated that this 2-Formyl-8-hydroxy-quinolinium chloride could execute strong anti-tumour activity with the identification of extensive necrotic feature from the tumour xenograft and limited adverse toxicological effect. © 2014 Elsevier GmbH.
Alkaloid analogues, Anti-tumour, Galipea longiflora
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Lam, Kim-Hung, Kenneth Ka-Ho Lee, Roberto Gambari, Stanton Hon-Lung Kok, Tsz-Wai Kok, Albert Sun-Chi Chan, Zhao-Xiang Bian, Wai-Yeung Wong, Raymond Siu-Ming Wong, Fung-Yi Lau, See-Wai Tong, Kit-Wah Chan, Chor-Hing Cheng, Chung-Hin Chui, and Johnny Cheuk-On Tang. "Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue." Phytomedicine 21.6 (2014): 877-882.