http://dx.doi.org/10.1002/med.21266">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

DNA-binding small molecules as inhibitors of transcription factors

Language

English

Abstract

Accumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA-binding small molecules to selectively inhibit transcription factor-DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA-binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed. © 2012 Wiley Periodicals, Inc.

Keywords

Groove binding, Inhibitor, Intercalation, Small molecule, Transcription factor

Publication Date

2013

Source Publication Title

Medicinal Research Reviews

Volume

33

Issue

4

Start Page

823

End Page

846

Publisher

Wiley

ISSN (print)

01986325

ISSN (electronic)

10981128

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