http://dx.doi.org/10.1002/anie.201208414">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Bioactive luminescent transition-metal complexes for biomedical applications

Language

English

Abstract

The serendipitous discovery of the anticancer drug cisplatin cemented medicinal inorganic chemistry as an independent discipline in the 1960s. Luminescent metal complexes have subsequently been widely applied for sensing, bio-imaging, and in organic light-emitting diode applications. Transition-metal complexes possess a variety of advantages that make them suitable as therapeutics and as luminescent probes for biomolecules. It is thus highly desirable to develop new luminescent metal complexes that either interact with DNA through different binding modes or target alternative cellular machinery such as proteins as well as to provide a more effective means of monitoring disease progression. In this Review, we highlight recent examples of biologically active luminescent metal complexes that can target and probe a specific biomolecule, and offer insights into the future potential of these compounds for the investigation and treatment of human diseases. Metal-based theranostics: This Review highlights recent examples of biologically active luminescent metal complexes that can target and probe a specific biomolecule, and offers insight into the future potential of luminescent metal-based therapeutics for the investigation and treatment of human diseases. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

luminescence, metal complexes, theranostics, therapeutic agent, transition metals

Publication Date

2013

Source Publication Title

Angewandte Chemie International Edition

Volume

52

Issue

30

Start Page

7666

End Page

7682

Publisher

Wiley-VCH Verlag

ISSN (print)

14337851

ISSN (electronic)

15213773

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