http://dx.doi.org/10.1371/journal.pone.0092905">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Discovery of a natural product-like inos inhibitor by molecular docking with potential neuroprotective effects in vivo

Language

English

Abstract

In this study, we applied structure-based virtual screening techniques to identify natural product or natural product-like inhibitors of iNOS. The iNOS inhibitory activity of the hit compounds was characterized using cellular assays and an in vivo zebrafish larvae model. The natural product-like compound 1 inhibited NO production in LPS-stimulated Raw264.7 macrophages, without exerting cytotoxic effects on the cells. Significantly, compound 1 was able to reverse MPTP-induced locomotion deficiency and neurotoxicity in an in vivo zebrafish larval model. Hence, compound 1 could be considered as a scaffold for the further development of iNOS inhibitors for potential anti-inflammatory or anti-neurodegenerative applications. © 2014 Zhong et al.

Publication Date

2014

Source Publication Title

PLoS ONE

Volume

9

Issue

4

Publisher

Public Library of Science

ISSN (print)

19326203

ISSN (electronic)

19326203

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