http://dx.doi.org/10.1039/C3CC47444E">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe

Language

English

Abstract

A label-free, oligonucleotide-based, switch-on luminescence detection method for T4 polynucleotide kinase activity has been developed using a novel G-quadruplex-selective luminescent Ir(III) complex probe. The application of the assay for screening potential T4 PNK inhibitors is also demonstrated. To our knowledge, this is the first metal-based assay for PNK activity. © the Partner Organisations 2014.

Publication Date

2014

Source Publication Title

Chemical Communications

Volume

50

Issue

40

Start Page

5313

End Page

5315

Publisher

Royal Society of Chemistry

ISSN (print)

13597345

ISSN (electronic)

1364548X

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