http://dx.doi.org/10.1007/s00216-013-7542-5">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

LC–MS/MS in the routine clinical laboratory: Has its time come?

Language

English

Abstract

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been increasingly used in routine clinical laboratories during the last two decades. The high specificity, sensitivity, and multi-analyte potential make it an ideal alternative to immunoassays or conventional high-performance liquid chromatography (HPLC). It also provides higher throughput than gas chromatography-mass spectrometry (GC-MS). LC-MS/MS also offers higher flexibility than immunoassays because LC-MS/MS assays are typically developed in-house. In addition, abundant information can be obtained from a single LC-MS/MS run which can produce a large amount of quantitative or qualitative data. In this review, typical LC-MS/MS clinical applications are presented, personal experiences are shared, and strengths and weakness are discussed. It is foreseeable that LC-MS/MS will become a key instrument in routine clinical laboratories. © 2013 Springer-Verlag Berlin Heidelberg.

Keywords

LC-MS/MS, Routine clinical applications, Strengths, Weakness

Publication Date

2014

Source Publication Title

Analytical and Bioanalytical Chemistry

Volume

406

Issue

10-9

Start Page

2289

End Page

2301

Publisher

Springer Verlag

ISSN (print)

16182642

ISSN (electronic)

16182650

This document is currently not available here.

Share

COinS