http://dx.doi.org/10.1002/anie.201402144">
 

Document Type

Journal Article

Department/Unit

Department of Chemistry

Title

In vivo chemoembolization and magnetic resonance imaging of liver tumors by using iron oxide nanoshell/doxorubicin/poly(vinyl alcohol) hybrid composites

Language

English

Abstract

A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

antitumor agents, chemoembolization, drug delivery, iron oxide, liver cancer

Publication Date

2014

Source Publication Title

Angewandte Chemie International Edition

Volume

53

Issue

19

Start Page

4812

End Page

4815

Publisher

Wiley-VCH Verlag

ISSN (print)

14337851

ISSN (electronic)

15213773

This document is currently not available here.

Share

COinS