Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin

Language

English

Abstract

The anticancer action of gallotannins is a well-developed topic. We have demonstrated the in vivo antitumour activity of corilagin on Hep3B hepatoma using the xenograft athymic nude mice model. Here, we further report the potential sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Our results showed that corilagin is able to enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells. We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect. Copyright © 2013 John Wiley & Sons, Ltd.

Keywords

cisplatin, corilagin, doxorubicin, Hep3B hepatoma cells

Publication Date

2014

Source Publication Title

Phytotherapy Research

Volume

28

Issue

5

Start Page

781

End Page

783

Publisher

Wiley

DOI

10.1002/ptr.5049

Link to Publisher's Edition

http://dx.doi.org/10.1002/ptr.5049

ISSN (print)

0951418X

ISSN (electronic)

10991573

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