http://dx.doi.org/10.1049/iet-syb.2012.0055">
 

Document Type

Journal Article

Department/Unit

Department of Mathematics

Title

Construction and analysis of single nucleotide polymorphism – single nucleotide polymorphism interaction networks

Language

English

Abstract

The study of gene regulatory network and protein-protein interaction network is believed to be fundamental to the understanding of molecular processes and functions in systems biology. In this study, the authors are interested in single nucleotide polymorphism (SNP) level and construct SNP-SNP interaction network to understand genetic characters and pathogenetic mechanisms of complex diseases. The authors employ existing methods to mine, model and evaluate a SNP sub-network from SNP-SNP interactions. In the study, the authors employ the two SNP datasets: Parkinson disease and coronary artery disease to demonstrate the procedure of construction and analysis of SNP-SNP interaction networks. Experimental results are reported to demonstrate the procedure of construction and analysis of such SNP-SNP interaction networks can recover some existing biological results and related disease genes. © 2013 The Institution of Engineering and Technology.

Publication Date

2013

Source Publication Title

IET Systems Biology

Volume

7

Issue

5

Start Page

170

End Page

181

Publisher

Institution of Engineering and Technology

ISSN (print)

17518849

ISSN (electronic)

17518857

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