http://dx.doi.org/10.1155/2013/647452">
 

Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

A metabolomics profiling study in hand-foot-and-mouth disease and modulated pathways of clinical intervention using liquid chromatography/quadrupole time-of-flight mass spectrometry

Language

English

Abstract

Hand-foot-and-mouth disease (HFMD), with poorly understood pathogenesis, has become a major public health threat across Asia Pacific. In order to characterize the metabolic changes of HFMD and to unravel the regulatory role of clinical intervention, we have performed a metabolomics approach in a clinical trial. In this study, metabolites profiling was performed by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) platform from the HFMD clinical patient samples. The outcome of this study suggested that 31 endogenous metabolites were mainly involved and showed marked perturbation in HFMD patients. In addition, combination therapy intervention showed normalized tendency in HFMD patients in differential pathway. Taken together, these results indicate that metabolomics approach can be used as a complementary tool for the detection and the study of the etiology of HFMD. © 2013 Cheng Lu et al.

Publication Date

2013

Source Publication Title

Evidence-Based Complementary and Alternative Medicine

Volume

2013

Start Page

647452-1

End Page

647452-10

Publisher

Hindawi Publishing Corporation

ISSN (print)

1741427X

ISSN (electronic)

17414288

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