http://dx.doi.org/10.1038/nm.3026">
 

Document Type

Journal Article

Authors

Xiaogang Wang, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Baosheng Guo, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Qi Li, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Jiang Peng, Institute of Orthopedics, General Hospital of Chinese People's Liberation Army
Zhijun Yang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Aiyuan Wang, Institute of Orthopedics, General Hospital of Chinese People's Liberation Army
Dong Li, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
Zhibo Hou, Department of Orthopedics, Second Hospital of Medical College (Shenzhen), Jinan University
Ke Lv, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Guanghan Kan, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Hongqing Cao, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Heng Wu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
Jinping Song, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Xiaohua Pan, Department of Orthopedics, Second Hospital of Medical College (Shenzhen), Jinan University
Qiao Sun, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Shukuan Ling, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Yuheng Li, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Mu Zhu, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Pengfei Zhang, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Songlin Peng, Department of Orthopedics, Second Hospital of Medical College (Shenzhen), Jinan University
Xiaoqing Xie, Department of Orthopedics, Second Hospital of Medical College (Shenzhen), Jinan University
Tao Tang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
An Hong, Department of Orthopedics, Second Hospital of Medical College (Shenzhen), Jinan University
Zhaoxiang Bian, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Yanqiang Bai, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Aiping Lu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Yinghui Li, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center
Fuchu He, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
Ge Zhang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Yingxian Li, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center

Department/Unit

School of Chinese Medicine

Title

miR-214 targets ATF4 to inhibit bone formation

Language

English

Abstract

Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating osteogenic differentiation and bone formation. Thus far, no study has established the pathophysiological role for miRNAs identified in human osteoporotic bone specimens. Here we found that elevated miR-214 levels correlated with a lower degree of bone formation in bone specimens from aged patients with fractures. We also found that osteoblast-specific manipulation of miR-214 levels by miR-214 antagomir treatment in miR-214 transgenic, ovariectomized, or hindlimb-unloaded mice revealed an inhibitory role of miR-214 in regulating bone formation. Further, in vitro osteoblast activity and matrix mineralization were promoted by antagomir-214 and decreased by agomir-214, and miR-214 directly targeted ATF4 to inhibit osteoblast activity. These data suggest that miR-214 has a crucial role in suppressing bone formation and that miR-214 inhibition in osteoblasts may be a potential anabolic strategy for ameliorating osteoporosis. © 2013 Nature America, Inc. All rights reserved.

Publication Date

2013

Source Publication Title

Nature Medicine

Volume

19

Start Page

93

End Page

100

Publisher

Nature Publishing Group

ISSN (print)

10788956

ISSN (electronic)

1546170X

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