Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Traditional Chinese medicine-based network pharmacology could lead to new multicompound drug discovery

Language

English

Abstract

Current strategies for drug discovery have reached a bottleneck where the paradigm is generally "one gene, one drug, one disease." However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases. Interestingly, traditional chinese medicine (TCM) has been practicing holistic views for over 3,000 years, and its distinguished feature is using herbal formulas to treat diseases based on the unique pattern classification. Though TCM herbal formulas are acknowledged as a great source for drug discovery, no drug discovery strategies compatible with the multidimensional complexities of TCM herbal formulas have been developed. In this paper, we highlighted some novel paradigms in TCM-based network pharmacology and new drug discovery. A multiple compound drug can be discovered by merging herbal formula-based pharmacological networks with TCM pattern-based disease molecular networks. Herbal formulas would be a source for multiple compound drug candidates, and the TCM pattern in the disease would be an indication for a new drug. © 2012 Jian Li et al.

Publication Date

2012

Source Publication Title

Evidence-Based Complementary and Alternative Medicine

Volume

2012

Start Page

149762-1

End Page

149762-11

Publisher

Hindawi Publishing Corporation

DOI

10.1155/2012/149762

Link to Publisher's Edition

http://dx.doi.org/10.1155/2012/149762

ISSN (print)

1741427X

ISSN (electronic)

17414288

This document is currently not available here.

Share

COinS