Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Understanding the molecular mechanism of interventions in treating rheumatoid arthritis patients with corresponding traditional chinese medicine patterns based on bioinformatics approach

Language

English

Abstract

Better effectiveness would be achieved when interventions are used in treating patients with a specific traditional Chinese medicine (TCM) pattern. In this paper, the effectiveness in treating rheumatoid arthritis (RA) patients in a randomized clinical trial as reanalyzed after the patients were classified into different TCM patterns and the underlying mechanism of how the TCM pattern influences the clinical effectiveness of interventions (TCM and biomedicine therapy) was explored. The pharmacological networks of interventions were builtup with protein and protein interaction analyses based on all the related targeted proteins obtained from PubChem. The underlying mechanism was explored by merging the pharmacological networks with the molecular networks of TCM cold and hot patterns in RA. The results show that the TCM therapy is better in treating the RA patients with TCM hot pattern, and the biomedical therapy is better in the RA patients with cold pattern. The pharmacological network of TCM intervention is merged well with the molecular network of TCM hot pattern, and the pharmacological network of biomedical therapy is merged well with the network of cold pattern. The finding indicates that molecular network analysis could give insight into the full understanding of the underlying mechanism of how TCM pattern impacts the efficacy. © 2012 Miao Jiang et al.

Publication Date

2012

Source Publication Title

Evidence-Based Complementary and Alternative Medicine

Volume

2012

Start Page

129452-1

End Page

129452-11

Publisher

Hindawi Publishing Corporation

DOI

10.1155/2012/129452

Link to Publisher's Edition

http://dx.doi.org/10.1155/2012/129452

ISSN (print)

1741427X

ISSN (electronic)

17414288

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