Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome

Language

English

Abstract

Aims: Post-infectious irritable bowel syndrome (PI-IBS) is a subset of IBS which occurs after an episode of acute gastrointestinal infections. The mechanisms of PI-IBS are not fully understood. Currently, numerous animal models have been used in the study of PI-IBS. This article reviews the strengths and weaknesses of these models. Methods: All relevant articles were identified by searching in Ovid SP from 1962, the year the term PI-IBS was coined, up to December 31, 2009. The types of model were categorized as either post-infectious or post-inflammatory, and the characteristics of each kind of model were listed. Results: Based on our literature search, 268 articles were identified. Of those articles, 50 were included in this review. The existing PI-IBS models include infection with bacteria (e.g., Campylobacter jejuni, Salmonella enterica, and Campylobacter rodentium), and infection with parasites (e.g., Trichinella spiralis, Nippostrongylus brasiliensis, and Cryptosporidium parvum). The post-inflammatory IBS models are commonly induced with chemical agents, such as acetic acid, deoxycholic acid, dextran sulfate sodium, mustard oil, zymosan, and trinitrobenzene sulfonic acid (TNBS). TNBS is the most commonly used agent for post-inflammatory IBS models, but the experimental protocol varies. These models have one or more aspects similar to IBS patients. Conclusions: Different methods have been used for the development of post-infectious or post-inflammatory IBS models. Each model has its weaknesses and strengths. More studies are needed to establish post-infection IBS models using more common pathogens. A standard protocol in developing TNBS-induced post-inflammatory IBS model is needed. © 2010 Springer.

Keywords

Animal model, Irritable bowel syndrome, Post-infection, Post-inflammation

Publication Date

2011

Source Publication Title

Journal of Gastroenterology

Volume

46

Issue

2

Start Page

164

End Page

174

Publisher

Springer Verlag

DOI

10.1007/s00535-010-0321-6

Link to Publisher's Edition

http://dx.doi.org/10.1007/s00535-010-0321-6

ISSN (print)

09441174

ISSN (electronic)

14355922

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