http://dx.doi.org/10.1016/j.fitote.2013.03.027">
 

Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Alkyl and phenolic glycosides from Saussurea stella

Language

English

Abstract

One alkyl glycoside, saussurostelloside A (1), two phenolic glycosides, saussurostellosides B1 (2) and B2 (3), and 27 known compounds, including eleven flavonoids, seven phenolics, six lignans, one neolignan, one phenethyl glucoside and one fatty acid, were isolated from an ethanol extract of Saussurea stella (Asteraceae). Their structures were elucidated by NMR, MS, UV, and IR spectroscopic analysis. Of the known compounds, (+)-medioresinol-di-O-β-d- glucoside (7), picraquassioside C (10), and diosmetin-3′-O-β-d- glucoside (27) were isolated from the Asteraceae family for the first time, while (+)-pinoresinol-di-O-β-d-glucoside (6), di-O-methylcrenatin (11), protocatechuic acid (14), 1,5-di-O-caffeoylquinic acid (17), formononetin (28), and phenethyl glucoside (29) were isolated from the Saussurea genus for the first time. The anti-inflammatory activities of three new compounds (1-3), five lignans ((-)-arctiin (4), (+)-pinoresinol-4-O-β-d-glucoside (5), (+)-pinoresinol-di-O-β-d-glucoside (6), (+)-medioresinol-di-O-β-d- glucoside (7) and (+)-syringaresinol-4-O-β-d-glucoside (8)), one neolignan (picraquassioside C (10)), and one phenolic glycoside (di-O-methylcrenatin (11)) were evaluated by testing their inhibition of the release of β-glucuronidase from PAF-stimulated neutrophils. Only compound 5 showed moderate inhibition of the release of β-glucuronidase, with an inhibition ratio of 39.1%. © 2013 Elsevier Ltd. All rights reserved.

Keywords

Alkyl glycoside, Anti-inflammatory activity, Asteraceae, Phenolic glycoside, Saussurea stella

Publication Date

2013

Source Publication Title

Fitoterapia

Volume

88

Start Page

38

End Page

43

Publisher

Elsevier

ISSN (print)

0367326X

ISSN (electronic)

18736971

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