School of Chinese Medicine
Comparative chemical analysis of Radix Astragali and Radix Hedysari by HPLC
Radix Astragali and Radix Hedysari, two famous traditional Chinese medicines (TCM), were considered to possess the same efficacy in TCM traditionally. However, modern pharmacological and phytochemical investigations showed that they were different in efficacy and chemical constituents to some degree. In this study, the principal constituents of the two drugs, isoflavonoids and saponins, were comparatively analysed using HPLC-UV and HPLC-ELSD methods. The results showed that there were some common compounds, especially flavonoids, in both drugs, while the differences in the types and contents of their chemical constituents, especially in saponins, were also obvious. The similarities and differences of the chemicals may be responsible, at least partially, for the similarities and differences in their efficacies or bioactivities. © 2012 Copyright Taylor and Francis Group, LLC.
Astragalus membranaceus, Astragalus membranaceus var. mongholicus, Hedysarum polybotrys, HPLC, Radix Astragali, Radix Hedysari
Source Publication Title
Natural Product Research
Taylor & Francis
Link to Publisher's Edition
Liu, Yi, Xiaojing Zhang, Yuying Zhao, Hubiao Chen, Bin Wang, and Qingying Zhang. "Comparative chemical analysis of Radix Astragali and Radix Hedysari by HPLC." Natural Product Research 26.20 (2012): 1935-1938.