Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells

Language

English

Abstract

In this study, anticancer activities of six compounds of flavonoids were investigated in human epidermoid carcinoma KB and KBv200 cells. Among these compounds, quercetin and acacetin showed strong inhibition of cell growth in KB and KBv200 cells. IC50 values of quercetin against KB and KBv200 cells were 17.84 ± 4.14 and 18.94 ± 4.75 μM, respectively. The IC50 values of acacetin against KB and KBv200 cells were 41.33 ± 6.05 and 49.04 ± 3.64 μM. The IC50 values of apigenin, kaempferol, kaempferol 3-O-rhamnoside, and quercetin 3-O-rhamnoside were more than 100 μM. Furthermore, quercetin was found to induce apoptosis in KB and KBv200 cells via the mitochondrial pathway, including a decrease of the reactive oxygen species level, loss of mitochondrial membrane potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly (ADP-ribose) polymerase. The apoptosis induced by quercetin was not related to the regulation of Bcl-2 or Bax in KB and KBv200 cells. © 2013 American Chemical Society.

Keywords

anticancer, apoptosis, flavonoids, mitochondrial pathway, quercetin

Publication Date

2013

Source Publication Title

Journal of Agricultural and Food Chemistry

Volume

61

Issue

9

Start Page

2188

End Page

2195

Publisher

American Chemical Society

DOI

10.1021/jf305263r

Link to Publisher's Edition

http://dx.doi.org/10.1021/jf305263r

ISSN (print)

00218561

ISSN (electronic)

15205118

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