http://dx.doi.org/10.1248/bpb.33.512">
 

Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Development of liposomal salbutamol sulfate dry powder inhaler formulation

Language

English

Abstract

The purpose of our study was to develop a formulation of liposomal salbutamol sulfate (SBS) dry powder inhaler (DPI) for the treatment of asthma. Liposomes of high encapsulation efficiency (more than 80%) were prepared by a vesicular phospholipid gel (VPG) technique. SBS VPG liposomes were subjected to lyophilization using different kinds of cryoprotectants in various mass ratios. Coarse lactose (63-106 μm) in different mass ratios was used as a carrier. Magnesium stearate (0.5%) was added as a lubricator. The dry liposomal powders were then crushed by ball milling and sieved through a 400-mesh sieve to control the mean particle size at about 10 mm. The effects of different kinds of cryoprotectants and the amount of lactose carrier on the fine particle fraction (FPF) of SBS were investigated. The results showed that the developed formulation of liposomal dry powder inhaler was obtained using lactose as a cryoprotectant with a mass ratio of lyophilized powder to carrier lactose at 1 : 5; 0.5% magnesium stearate was used as a lubricator. The value of FPF for SBS was 41.51±2.22% for this formulation. Sustained release of SBS from the VPG liposomes was found in the in vitro release study. The study results offer the promising possibility of localized pulmonary liposomal SBS delivery in the anhydrous state. © 2010 Pharmaceutical Society of Japan.

Keywords

Dry powder inhaler, Liposome, Pulmonary delivery, Salbutamol sulfate

Publication Date

2010

Source Publication Title

Biological and Pharmaceutical Bulletin

Volume

33

Issue

3

Start Page

512

End Page

517

Publisher

Pharmaceutical Society of Japan

ISSN (print)

09186158

ISSN (electronic)

13475215

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