School of Chinese Medicine
Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng
Quantitative comparison of seven ginsenosides in wild and cultivated American ginseng revealed that the Rg1/Rd ratio presented a significantly large difference between cultivated and type-I (one of the defined chemotypes) wild American ginseng, facilitating this ratio as a characteristic marker for differentiating these two groups. Similarly, the ratio (Rg 1 + Re)/Rd, and the ratio of protopanaxatriol (PPT)-type ginsenosides to protopanaxadiol (PPD)-type ginsenosides showed a large difference between these two groups. On the other hand, type-II wild samples were found to have high Rg1/Rb1 and Rg1/Re ratios and low panaxydol/panaxynol ratio, which is entirely different from Type-I American ginseng, but is very similar to that of Asian ginseng. This not only suggests that the chemotype should be taken into consideration properly when using these parameters for differentiating American and Asian ginseng, but also indicates that type-II wild American ginseng may have distinct pharmacological activities and therapeutic effects. © 2010 Verlag Helvetica Chimica Acta AG.
Source Publication Title
Chemistry and Biodiversity
Wang, Jing-Rong, Chiu-Yin Leung, Hing-Man Ho, Stella Chai, Lee-Fong Yau, Zhong-Zhen Zhao, and Zhi-Hong Jiang. "Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng." Chemistry and Biodiversity 7.4 (2010): 975-983.