School of Chinese Medicine
Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson’s disease
Motor complications induced by levodopa (L-dopa) treatment in Parkinson's disease (PD) are not well documented in patients of Chinese ethnicity. We performed a cross-sectional study to investigate the prevalence of dyskinesias and motor fluctuations, and the factors determining their development, in a population of Chinese patients with PD. Among 137 patients with PD, 98 (71.5%) had received a L-dopa preparation. Motor fluctuations were found in 74.5% and dyskinesias in 77.6% of the 98 patients. Patients with dyskinesias were younger at onset of disease than those without. Patients with dyskinesias and motor fluctuations had significantly longer duration of PD and L-dopa treatment, higher daily doses of L-dopa, and higher scores in the 39-item Parkinson's Disease Questionnaire (PDQ-39), when compared to patients without motor complications. Among these factors, motor fluctuations were best predicted by duration of L-dopa treatment and dyskinesias by disease duration. We conclude that motor complications are closely related to disease and treatment parameters, especially the treatment and disease duration. © 2008 Elsevier Ltd. All rights reserved.
Chinese, cross-sectional study, Dyskinesias, Motor fluctuations, Parkinson's disease
Source Publication Title
Journal of Clinical Neuroscience
Kum, Wan Fung, Jing Gao, Siva Sundara Kumar Durairajan, Sui Cheung Man, Li Xia Xie, Jia Hong Lu, Wai Leuk Fong, and Min Li. "Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson’s disease." Journal of Clinical Neuroscience 16.8 (2009): 1034-1037.