School of Chinese Medicine
Treatment of idiopathic parkinson's disease with traditional Chinese herbal medicine: A randomized placebo-controlled pilot clinical study
The objective of this clinical study is to examine the effects of a Chinese herbal medicine formula (Jia Wei Liu Jun Zi Tang: JWLJZT) on motor and non-motor symptoms, and on complications of conventional therapy in idiopathic Parkinson's disease (PD), using an add-on design. Fifty-five patients with PD were randomly allocated to receive either Chinese herbal medicine or placebo for 24 weeks. Primary outcome measure was the 39-item Parkinson's Disease Questionnaire (PDQ-39). Secondary outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS), Short-Form-36 Health Survey (SF-36), Geriatric Depression Scale (GDS), home diaries, and a range of category rating scales. JWLJZT resulted in a significant improvement in the UPDRS IVC when compared with placebo at 12 weeks (P =.039) and 24 weeks (P =.034). In addition, patients in the Chinese herbal medicine group also showed significant improvement in PDQ-39 communication scores at 12 weeks (P =.024) and 24 weeks (P =.047) when compared with the placebo group. There were no significant differences between treatment and control groups for SF-36 variables, GDS score or the mean daily "on-off" time. One case of mild diarrhea was noted in the treatment group. The findings suggest that JWLJZT can relieve some non-motor complications of conventional therapy and improve the communication ability in patients with PD. The results of this pilot study warrant larger multi-center clinical studies to assess long-term efficacy and tolerability of JWLJZT, and to elucidate the mechanisms by which it affects PD function. Copyright © 2011 Wan Fung Kum et al.
Source Publication Title
Evidence-Based Complementary and Alternative Medicine
Hindawi Publishing Corporation
Li, Min, Wan Fung Kum, Siva Sundara Kumar Durairajan, Zhao Xiang Bian, Sui Cheung Man, Yuen Chi Lam, Li Xia Xie, Jia Hong Lu, Yan Wang, and Xian Zhang Huang. "Treatment of idiopathic parkinson's disease with traditional Chinese herbal medicine: A randomized placebo-controlled pilot clinical study." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 724353-1-724353-8.