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Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Comparison of the chemical profiles and anti-platelet aggregation effects of two “Dragon's Blood” drugs used in traditional Chinese medicine

Language

English

Abstract

Ethnopharmacological relevance: "Dragon's Blood" has been used as a medicine since ancient times by many cultures. In traditional Chinese medicine, the resin obtained from Daemonorops draco (RDD) and the resin from Dracaena cochinchinensis (RDC) are equally prescribed as "Dragon's Blood" for facilitating blood circulation. Aim of the study: To verify the traditional efficacy and elucidate the mechanism, the present study compared the chemical profiles and the pharmacological effects of two species of "Dragon's Blood" mainly used in China. Materials and methods: A UPLC-MS fingerprinting method was developed to compare the chemical profiles of the two medicines. The anti-platelet aggregation effects of the two medicines induced by arachidonic acid (AA) were investigated. Results: The chemical profiles of these two species of "Dragon's Blood" were significantly different. The characteristic constituents were found to be: flavanes in RDD and stilbenes in RDC. In the in vivo platelet inhibition test, performed with the dose of 200 mg/kg on rats, the peak inhibitory effects of RDD and RDC were 35.8% and 27.6%, respectively, compared with the control group. With the in vitro concentrations of 0.2, 0.4 and 0.8 mg/ml, RDD exerted significant inhibition of aggregation by 18.7%, 20.0%, and 61.6%, respectively, and RDC exerted significant inhibition of aggregation by 13.3%, 20.2%, and 31.6%, respectively. Conclusion: The fingerprinting method used here is suitable for distinguishing them. All pharmacological tests indicated that RDD was more potent than RDC against platelet aggregation. © 2010 Elsevier Ireland Ltd. All rights reserved.

Keywords

Anti-platelet aggregation, Chemical profiles, Daemonorops draco, Dracaena cochinchinensis, Dragon's Blood

Publication Date

2011

Source Publication Title

Journal of Ethnopharmacology

Volume

133

Issue

2

Start Page

796

End Page

802

Publisher

Elsevier

ISSN (print)

03788741

ISSN (electronic)

18727573

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