Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Comparison of the immunoregulatory function of different constituents in Radix Astragali and Radix Hedysari

Language

English

Abstract

Radix Astragali (RA), known as Huangqi in China, is one of the most popular herbal medicines known worldwide to reinforce Qi. RA is traditionally prepared from the dried roots of Astragalus membranaceus (MJHQ) and A. membranaceus var. mongholicus (MGHQ). Radix Hedysari is named Hongqi (HQ), which is similar to RA. We assessed and compared the chemical constituents and bioactivity of RA and HQ. Different constituents were extracted into five major parts and were analyzed using different methods. Comparison of the immunological effects of extracts was done by using two immunological models. Results showed that flavonoids and saponins present in RA and HQ were not only structurally significantly different but also different in their immunological effect. Amino acids extract (AE) in MGHQ shows immunological effect while AE in MJHQ and HQ did not. Polysaccharides comprised the major constituents in RA and HQ. All polysaccharides extract (PE) of the three herbs showed similar levels of immunological effect in both immunological assays. © 2010 Jing Liu et al.

Publication Date

2010

Source Publication Title

Journal of Biomedicine and Biotechnology

Volume

2010

Start Page

479426-1

End Page

479426-12

Publisher

Hindawi Publishing Corporation

DOI

10.1155/2010/479426

Link to Publisher's Edition

http://dx.doi.org/10.1155/2010/479426

ISSN (print)

11107243

ISSN (electronic)

11107251

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