Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Traditional Medicine Collection Tracking System (TM-CTS): A database for ethnobotanically driven drug-discovery programs

Language

English

Abstract

Ethnopharmacological relevance: Ethnobotanically driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. Materials and methods: The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. Results: The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. The system incorporates a number of unique features that are useful in the context of ethnobotanical projects such as support for information about botanical collection, method of processing, quality tests for plants with existing pharmacopoeia standards, chemical extraction and fractionation, and historical uses of the plants. The database also accommodates data provided in multiple languages and integration with a database system built to support high throughput screening based drug discovery efforts. It is accessed via a web-based application that provides extensive, multi-format reporting capabilities. Conclusions: This new database system was designed to support a project evaluating the bioactivity of Chinese medicinal plants. The software used to create the database is open source, freely available, and could potentially be applied to other ethnobotanically driven natural product collection and drug-discovery programs. © 2011 Elsevier Ireland Ltd. All rights reserved.

Keywords

Database, Drug discovery, Ethnobotany, High throughput screening, Traditional Chinese Medicine

Publication Date

2011

Source Publication Title

Journal of Ethnopharmacology

Volume

135

Issue

2

Start Page

590

End Page

593

Publisher

Elsevier

DOI

10.1016/j.jep.2011.03.029

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.jep.2011.03.029

ISSN (print)

03788741

ISSN (electronic)

18727573

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