Document Type

Journal Article

Authors

C. Gyllenhaal, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
M. R. Kadushin, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
B. Southavong, Institute of Traditional Medicine, Ministry of Health
K. Sydara, Institute of Traditional Medicine, Ministry of Health
S. Bouamanivong, National Herbarium of Laos, National Science Council
M. Xaiveu, Institute of Traditional Medicine, Ministry of Health
L. T. Xuan, Vietnam Academy of Science and Technology
N. T. Hiep, Vietnam Academy of Science and Technology
N. V. Hung, Vietnam Academy of Science and Technology
P. K. Loc, Vietnam Academy of Science and Technology
L. X. Dac, Vietnam Academy of Science and Technology
T. Q. Bich, Cuc Phuong National Park
N. M. Cuong, Cuc Phuong National Park
H. M. Ly, National Institute of Health and Epidemics
H. J. Zhang, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
S. G. Franzblau, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
H. Xie, Center for Clinical and Translational Sciences, University of Illinois at Chicago
M. C. Riley, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
B. G. Elkington, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
H. T. Nguyen, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
D. P. Waller, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago
C. Y. Ma, U.S. Pharmacopoeia
P. Tamez, University of Notre Dame
G. T. Tan, College of Pharmacy, University of Hawaii
J. M. Pezzuto, College of Pharmacy, University of Hawaii
D. D. Soejarto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago

Department/Unit

School of Chinese Medicine

Title

Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis

Language

English

Abstract

Context: Whether natural product drug discovery programs should rely on wild plants collected "randomly" from the natural environment, or whether they should also include plants collected on the basis of use in traditional medicine remains an open question. Objective: This study analyzes whether plants with ethnomedical uses from Vietnam and Laos have a higher hit rate in bioassay testing than plants collected from a national park in Vietnam with the goal of maximizing taxonomic diversity ("random" collection). Materials and Methods: All plants were extracted and subjected to bioassay in the same laboratories. Results of assays of plant collections and plant parts (samples) were scored as active or inactive based on whether any extracts had a positive result in a bioassay. Contingency tables were analyzed using χ 2 statistics. Results: Random collections had a higher hit rate than ethnomedical collections, but for samples, ethnomedical plants were more likely to be active. Ethnomedical collections and samples had higher hit rates for tuberculosis, while samples, but not collections, had a higher hit rate for malaria. Little evidence was found to support an advantage for ethnomedical plants in HIV, chemoprevention and cancer bioassays. Plants whose ethnomedical uses directly correlated to a bioassay did not have a significantly higher hit rate than random plants. Discussion: Plants with ethnomedical uses generally had a higher rate of activity in some drug discovery bioassays, but the assays did not directly confirm specific uses. Conclusions: Ethnomedical uses may contribute to a higher rate of activity in drug discovery screening.

Keywords

Cancer, Chemoprevention, Drug discovery, HIV, Laos, Malaria, Screening, Traditional medicine, Tuberculosis, Vietnam

Publication Date

2012

Source Publication Title

Pharmaceutical Biology

Volume

50

Issue

1

Start Page

30

End Page

41

Publisher

Informa Healthcare

DOI

10.3109/13880209.2011.634424

ISSN (print)

13880209

ISSN (electronic)

17445116

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