School of Chinese Medicine
Rubesanolides C–E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity
Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans. © 2012 The Royal Society of Chemistry.
Source Publication Title
Organic and Biomolecular Chemistry
Royal Society of Chemistry
Link to Publisher's Edition
Zou, Juan, Lutai Pan, Qiji Li, Jianxin Pu, Ping Yao, Min Zhu, Jeffrey A. Banas, Hongjie Zhang, and Handong Sun. "Rubesanolides C–E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity." Organic and Biomolecular Chemistry 10.26 (2012): 5039-5044.