Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Rubesanolides C–E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

Language

English

Abstract

Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans. © 2012 The Royal Society of Chemistry.

Publication Date

2012

Source Publication Title

Organic and Biomolecular Chemistry

Volume

10

Issue

26

Start Page

5039

End Page

5044

Publisher

Royal Society of Chemistry

DOI

10.1039/C2OB25192B

Link to Publisher's Edition

http://dx.doi.org/10.1039/C2OB25192B

ISSN (print)

14770520

ISSN (electronic)

14770539

This document is currently not available here.

Share

COinS