Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.

Publication Date

7-14-2012

Source Publication Title

Organic and Biomolecular Chemistry

Volume

10

Issue

26

Start Page

5039

End Page

5044

Publisher

Royal Society of Chemistry

Peer Reviewed

1

Copyright

This journal is © The Royal Society of Chemistry 2012

Funder

This research is funded by The Science and Technology Department of Guiyang [No. (2008) 36].

DOI

10.1039/C2OB25192B

Link to Publisher's Edition

http://dx.doi.org/10.1039/C2OB25192B

ISSN (print)

14770520

ISSN (electronic)

14770539

JA-5193-26008_suppl.txt (71 kB)
Crystal structure data

Additional Files

JA-5193-26008_suppl.txt (71 kB)
Crystal structure data

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