School of Chinese Medicine
Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus
This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus. © 2013 Elsevier Ltd. All rights reserved.
Antibacterial agents, Antibiotics, Quinolines, Staphylococcus aureus
Source Publication Title
Bioorganic and Medicinal Chemistry Letters
Lam, Kim-Hung, Roberto Gambari, Kenneth Ka-Ho Lee, Yi-Xin Chen, Stanton Hon-Lung Kok, Raymond Siu-Ming Wong, Fung-Yi Lau, Chor-Hing Cheng, Wai-Yeung Wong, Zhao-Xiang Bian, Albert Sun-Chi Chan, Johnny Cheuk-On Tang, and Chung-Hin Chui. "Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus." Bioorganic and Medicinal Chemistry Letters 24.1 (2014): 367-370.