Document Type

Journal Article

Authors

Kim-Hung Lam, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Roberto Gambari, Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara
Kenneth Ka-Ho Lee, School of Biomedical Sciences, Department of Medicine and Therapeutics, Chinese University of Hong Kong
Yi-Xin Chen, Department of Chemistry, Guangzhou University
Stanton Hon-Lung Kok, School of Biomedical Sciences, Department of Medicine and Therapeutics, Chinese University of Hong Kong
Raymond Siu-Ming Wong, School of Biomedical Sciences, Department of Medicine and Therapeutics, Chinese University of Hong Kong
Fung-Yi Lau, School of Biomedical Sciences, Department of Medicine and Therapeutics, Chinese University of Hong Kong
Chor-Hing Cheng, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Wai-Yeung Wong, Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist UniversityFollow
Zhao-Xiang Bian, Clinical Division, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Albert Sun-Chi Chan, Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University
Johnny Cheuk-On Tang, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
Chung-Hin Chui, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic UniversityFollow

Department/Unit

School of Chinese Medicine

Title

Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Language

English

Abstract

This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus. © 2013 Elsevier Ltd. All rights reserved.

Keywords

Antibacterial agents, Antibiotics, Quinolines, Staphylococcus aureus

Publication Date

2014

Source Publication Title

Bioorganic and Medicinal Chemistry Letters

Volume

24

Issue

1

Start Page

367

End Page

370

Publisher

Elsevier

DOI

10.1016/j.bmcl.2013.10.072

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.bmcl.2013.10.072

ISSN (print)

0960894X

ISSN (electronic)

14643405

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