http://dx.doi.org/10.3109/02652048.2014.918670">
 

Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Microencapsulation-protected L-ascorbic acid for the application of human epithelial HaCaT cell proliferation

Language

English

Abstract

© 2014 Informa UK Ltd. L-ascorbic acid is an abundant water-soluble nutrient found in vegetables and fruits. It enhances the cell proliferation, which is helpful in wound healing process. However, it is relatively unstable and easily degraded under external environments including acidity, alkalinity, evaporation, heat, oxidization, light or moisture. Its storage remains challenged. This study reported the development of L-ascorbic acid microcapsules using the natural protein, gelatin, and the natural polysaccharide, agar, as the wall protection carrier. The physical properties including entrapment efficiency, particle size, surface morphology, chemical compositions and release profile were identified. The cell proliferation of L-ascorbic acid microcapsules was stronger than the free drug. Significant cell growth in microencapsulated L-ascorbic acid-treated human epithelial HaCaT cells was observed when compared with untreated control. Since cell proliferation and wound repair are closely related, it is believed that L-ascorbic acid microcapsules would effectively increase the potential effect of wound healing activity in human skin.

Keywords

Cell culture, Controlled release, Gelatin, Microencapsulation

Publication Date

2014

Source Publication Title

Journal of Microencapsulation

Volume

31

Issue

8

Start Page

754

End Page

758

Publisher

Informa Healthcare

ISSN (print)

02652048

ISSN (electronic)

14645246

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