Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

A systems-pharmacology analysis of herbal medicines used in health improvement treatment: Predicting potential new drugs and targets

Language

English

Abstract

For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH and BTH was developed. It is indicated that QEH compounds have high lipophilicity while BTH compounds possess high chemical reactivity. Secondly, a systematic investigation integrating ADME (absorption, distribution, metabolism, and excretion) prediction, target fishing and network analysis was performed and validated on these herbs to obtain the compound-target associations for reconstructing the biologically-meaningful networks. The results suggest QEH enhance physical strength, immune system and normal well-being, acting as adjuvant therapy for chronic disorders while BTH stimulate hematopoiesis function in body. As an emerging approach, the systems pharmacology model might facilitate to understand the mechanisms of action of the tonic herbs, which brings about new development for complementary and alternative medicine. © 2013 Jianling Liu et al.

Publication Date

2013

Source Publication Title

Evidence-Based Complementary and Alternative Medicine

Volume

2013

Start Page

1

End Page

17

Publisher

Hindawi Publishing Corporation

DOI

10.1155/2013/938764

Link to Publisher's Edition

http://dx.doi.org/10.1155/2013/938764

ISSN (print)

1741427X

ISSN (electronic)

17414288

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