http://dx.doi.org/10.3390/molecules17067183">
 

Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Comparison of the chemical composition and pharmacological effects of the aqueous and ethanolic extracts from a Tibetan "Snow Lotus" (Saussurea laniceps) herb

Language

English

Abstract

To understand the impacts of different processing methods on the composition and effects of the herb Saussurea laniceps (SL), the present study report the first comparison of the chemical constituents of aqueous and ethanolic SL extracts using chromatographic analysis, and to compare their pharmacological effects in a mouse anti-inflammatory, anti-nociceptive model and an in vitro anti-oxidant test. Chemical comparison demonstrated that the types of chemicals in the two extracts were identical, but the contents of the main constituents in the aqueous extract were lower than those of the ethanolic extract. A transesterification of dicaffeoylquinic acids took place in the aqueous extract during boiling. As for pharmacological effects, oral administration of aqueous and ethanolic SL extracts significantly inhibited croton oil-induced mice ear edema, and significantly inhibited acetic acid-induced mice writhings, respectively. In the DPPH anti-oxidant activity test, the IC 50 values were calculated as 409.6 mg/L and 523.4 mg/L for the ethanolic and aqueous extracts, respectively. The inhibitory effects of the ethanolic extract were more potent than those of the aqueous extract in all pharmacological tests, although there was no significant difference. This study suggests that the two preparations should be distinguished when used. © 2012 by the authors.

Keywords

Anti-inflammatory, Anti-nociceptive, Anti-oxidant, Saussurea laniceps, Transesterification

Publication Date

2012

Source Publication Title

Molecules

Volume

17

Issue

6

Start Page

7183

End Page

7194

Publisher

MDPI

ISSN (print)

14203049

ISSN (electronic)

14203049

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