School of Chinese Medicine
Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway
In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c. © 2011 by the authors.
Apoptosis, Caper euphorbia seed, Euphorbia factor L3, Mitochondrial pathway
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Zhang, Jian-Ye, Yong-Ju Liang, Hu-Biao Chen, Li-Sheng Zheng, Yan-Jun Mi, Fang Wang, Xiao-Qin Zhao, Xiao-Kun Wang, Hui Zhang, and Li-Wu Fu. "Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway." Molecules 16.4 (2011): 3222-3231.