http://dx.doi.org/10.3390/molecules16043222">
 

Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

Language

English

Abstract

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c. © 2011 by the authors.

Keywords

Apoptosis, Caper euphorbia seed, Euphorbia factor L3, Mitochondrial pathway

Publication Date

2011

Source Publication Title

Molecules

Volume

16

Issue

4

Start Page

3222

End Page

3231

Publisher

MDPI

ISSN (print)

14203049

ISSN (electronic)

14203049

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