http://dx.doi.org/10.1038/srep08856">
 

Document Type

Journal Article

Authors

Yi-Xin He, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
Jin Liu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
Baosheng Guo, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Yi-Xiang Wang, Department of Diagnostic Radiology and Organ Imaging, 0Chinese University of Hong Kong
Xiaohua Pan, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
Defang Li, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
Tao Tang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
Yang Chen, Department of Orthopaedics and Traumatology, Baoan Hospital Affiliated, Southern Medical University
Songlin Peng, Department of Orthopedics, Second Hospital of Medical College, Ji Nan University
Zhaoxiang Bian, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Zicai Liang, Academician Chen Xinzi Workroom for Advancing Translational Medicine in Bone and Joint Diseases, Kunshan RNAi Institute, Kunshan Industrial Technology Research Institute
Bao-Ting Zhang, School of Chinese Medicine, Chinese University of Hong Kong
Aiping Lu, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
Ge Zhang, Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist UniversityFollow

Department/Unit

School of Chinese Medicine

Title

Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits

Language

English

Abstract

To examine the therapeutic effect of Src inhibitor on the VEGF mediating vascular hyperpermeability and bone destruction within steroid-associated osteonecrotic lesions in rabbits. Rabbits with high risk for progress to destructive repair in steroid-associated osteonecrosis were selected according to our published protocol. The selected rabbits were systemically administrated with either Anti-VEGF antibody (Anti-VEGF Group) or Src inhibitor (Src-Inhibition Group) or VEGF (VEGF-Supplement Group) or a combination of VEGF and Src inhibitor (Supplement and Inhibition Group) or control vehicle (Control Group) for 4 weeks. At 0, 2 and 4 weeks after administration, in vivo dynamic MRI, micro-CT based-angiography, histomorphometry and immunoblotting were employed to evaluate the vascular and skeletal events in different groups. The incidence of the destructive repair in the Anti-VEGF Group, Src-Inhibition Group and Supplement and Inhibition Group was all significantly lower than that in the Control Group. The angiogenesis was promoted in VEGF-Supplement Group, Src-Inhibition Group and Supplement and Inhibition Group, while the hyperpermeability was inhibited in Anti-VEGF Group, Src-Inhibition Group and Supplement and Inhibition Group. The trabecular structure was improved in Src-Inhibition Group and Supplement and Inhibition Group. Src inhibitor could reduce permeability without disturbing vascularization and prevent destructive repair in steroid-associated osteonecrosis.

Publication Date

2015

Source Publication Title

Scientific Reports

Volume

5

Start Page

1

End Page

9

Publisher

Nature Publishing Group

ISSN (print)

20452322

ISSN (electronic)

20452322

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