Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Title

Traditional Chinese medicine formulas for irritable bowel syndrome: From ancient wisdoms to scientific understandings

Language

English

Abstract

© 2015 World Scientific Publishing Company and Institute for Advanced Research in Asian Science and Medicine.Traditional Chinese Medicine (TCM) serves as the most common alternative therapeutic approach for Western medicine and benefits IBS patients globally. Due to the lack of scientific evidence in the past, TCM formulas were not internationally well recognized as promising IBS remedies. In this review, firstly, we present the etiology and therapy of IBS in terms of traditional Chinese medical theory. Secondly, we summarize the clinical randomized controlled trials (RCTs) of TCM formulas for IBS patients that are available in the literature (from 1998 to September 2013), in which 14 RCTs conducted of high quality were discussed in detail. Of the 14 selected trials, 12 of those concluded that TCM formulas provided superior improvement in the global symptoms of IBS patients over the placebo or conventional medicines. As well, all 14 RCTs suggested that TCM formulas have good safety and tolerability. Last but not least, we explore the pharmacological mechanisms of the anti-IBS TCM formulas available in the literature (from 1994 to September, 2013). Collectively, in combating IBS symptoms, most TCM formulas exert multi-targeting actions including the regulation of neurotransmitters and hormones in the enteric nervous system (ENS), modulation of smooth muscle motility in the gastrointestinal (GI) tract, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, attenuation of intestinal inflammation and restoration of intestinal flora, etc. In conclusion, TCM formulas appear to be promising for IBS treatment. This review provides a useful reference for the public in furthering a better understanding and acceptance of TCM formulas as IBS remedies.

Keywords

Action Mechanisms, Efficacy and Safety, Irritable Bowel Syndrome, Multi-targeting Therapy, Traditional Chinese Medicine Formulas

Publication Date

2015

Source Publication Title

American Journal of Chinese Medicine

Volume

43

Issue

1

Start Page

1

End Page

23

Publisher

World Scientific Publishing

DOI

10.1142/S0192415X15500019

Link to Publisher's Edition

http://dx.doi.org/10.1142/S0192415X15500019

ISSN (print)

0192415X

ISSN (electronic)

17936853

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